Abstract:

Age-related macular degeneration(AMD) is a multifactorial disease that results from the combined contribution of age, environment and genetic predisposition.  Complement factor H(CFH) is an important inhibitor in complement system. The variant in CFH can decrease the inhibiting effect in complement pathway, which may play an important role in AMD pathogenesis. Research indicates that SNPs (single nucleotide polymorphisms) in CFH  not only have strong associations with AMD susceptibility but also affect the visual acuity improvement in anti-VEGF(vascular endothelia growth factor) therapy. This article focus on the association between CFH and the pathogenesis or treatment response of anti-VEGF therapy in wet AMD and ponit out a new way to predict response to anti-VEGF treatment of wet AMD in clinical setting.  (Int Rev Ophthalmol,  2016,  40:    103-106)